Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries.

@article{Lurie1997UnethicalTO,
  title={Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries.},
  author={Peter Lurie and Sidney M. Wolfe},
  journal={The New England journal of medicine},
  year={1997},
  volume={337 12},
  pages={
          853-6
        }
}
It was published almost 3 years ago that zidovudine administered orally to HIV-infected pregnant women, intravenously during labor, and later administered to newborn infants reduces the incidence of HIV infection in infants by two-thirds. This regimen, known as the ACTG 076 regimen and capable of saving the life of one of every seven infants born to HIV-infected women, subsequently became the standard of care in the US. However, the high cost of zidovudine and the ACTG 076 regimen impedes… Expand
Short course antiretroviral regimens to reduce maternal transmission of HIV
TLDR
Placebo-controlled trials to develop simple, cheap, and effective potentially non-drug interventions against vertical HIV transmission should be encouraged in settings in which antiretroviral drugs and formula feeding cannot be safely delivered. Expand
The prevention of perinatal HIV transmission in the less-developed world.
  • M. Susser
  • Medicine
  • American journal of public health
  • 1998
This editorial refers to a set of articles that address the controversy surrounding prophylactic trials in developing countries to avert maternal-infant transmission of HIV by establishingExpand
Ethics of placebo-controlled trials of zidovudine to prevent the perinatal transmission of HIV in the Third World.
TLDR
This letter responds to an article claiming that placebo-controlled trials of antiretroviral agents to reduce perinatal transmission of HIV in developing countries are unethical and a less traumatic observational methodology can be used to assess the efficacy of a prophylactic strategy. Expand
Placebo controls in HIV perinatal transmission trials: a South African's viewpoint.
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Any appropriate and effective intervention eventually developed for use in South Africa need not be as good as the ACTG 076 regimen of therapy but its impact upon HIV vertical transmission must be known because that information will be the basis of policy to protect hundreds of thousands of infants from becoming infected with HIV. Expand
Preventing Mother To Child Transmission of HIV - Current strategies.
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The study highlights the results during transition period of evolving HIV therapeutics and adds the final nail in the coffin for SD-NVP, which was adopted in many countries for prevention of MTCT and adds to the risk of acquiring drug resistance to NVP as well as cross resistance to Efavirenz. Expand
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Debate continues over the ethics of placebo-controlled trials of short-course antiretroviral regimens for preventing the mother-to-child transmission of HIV in developing countries. Debate began inExpand
Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice.
TLDR
Current knowledge of mother-to-child HIV transmission in developing countries is reviewed, key findings from the trials are summarized, future research requirements are outlined, and public health challenges of implementing perinatal HIV prevention interventions in resource-poor settings are described. Expand
Perinatal HIV transmission—A global problem: Controversy and protection of the next generation
TLDR
In June 1998, approximately 50 participants from various nations attended a workshop held by the Elizabeth Glaser Pediatric AIDS Foundation and the Emory/Atlanta Center for AIDS Research to discuss clinical trials to prevent mother-to-child transmission of HIV. Expand
Successful prevention of hiv transmission from mother to infant in Brazil using a multidisciplinary team approach.
  • S. Nogueira, T. Abreu, +10 authors J. Lambert
  • Medicine
  • The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
  • 2001
TLDR
HIV vertical transmission in Brazil was reduced to a level similar to other countries with the most effective prevention programs using a multidisciplinary team approach. Expand
Optimal versus suboptimal treatment for HIV-infected pregnant women and HIV-exposed infants in clinical research studies.
  • A. Ammann
  • Medicine
  • Journal of acquired immune deficiency syndromes
  • 2009
TLDR
A randomized trial design is used to compare the emergence of viral resistance in women receiving highly active antiretroviral therapy (HAART) compared with zidovudine (ZDV) plus single-dose nevirapine (sdNVP) on the emergenceof viral resistance, and results could profoundly impact millions of lives of HIV-infected pregnant women and their noninfected infants. Expand
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