Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates.

@article{Boyer1992UnequalHI,
  title={Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates.},
  author={Jayne C Boyer and Katarzyna Bębenek and T. A. Kunkel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 15},
  pages={6919-23}
}
Sequence variation in the type 1 human immunodeficiency virus (HIV-1) results, in part, from inaccurate replication by reverse transcriptase. Although this enzyme is error-prone during synthesis in vitro with DNA templates, the fidelity of RNA-dependent DNA synthesis relevant to minus-strand replication in the virus life cycle has not been examined extensively. In the present study, we have developed a system to determine the fidelity of transcription and reverse transcription and have used it… CONTINUE READING

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