Unequal distribution of RT-PCR artifacts along the E1-E2 region of Hepatitis C virus.

Abstract

Although viral variability studies have focused traditionally on consensus sequences, the relevance of molecular clone sequences for studying viral evolution at the intra-host level is being increasingly recognized. However, for this approach to be reliable, RT-PCR artifacts do not have to contribute excessively to the observed variability. Molecular clone… (More)
DOI: 10.1016/j.jviromet.2009.06.003

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