Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

@article{Zhang1997UnequalDI,
  title={Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis},
  author={Xiaohong Zhang and Thomas Levin Brunner and Laura L. Carter and Richard W. Dutton and Paul Rogers and Linda M Bradley and Takaaki Sato and John C. Reed and Douglas J. Green and Susan L Swain},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={1837 - 1849}
}
T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period. Both effectors undergo delayed apoptosis induced by a non-Fas-mediated pathway. When Th1 and Th2 effectors are co… CONTINUE READING