• Corpus ID: 10058537

Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease.

@article{Huang1996UndifferentiatedCI,
  title={Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease.},
  author={Yuguang Huang and J A Fischer-Vize},
  journal={Development},
  year={1996},
  volume={122 10},
  pages={
          3207-16
        }
}
The Drosophila compound eye develops by a complex series of cell interactions where multiple positive and inhibitory cues guide cells in each facet into their positions and fates. The results of many genetic and molecular experiments have led to the view that facet assembly is directed by cells within developing ommatidial preclusters. Here fat facets mutants and the cloned fat facets gene were used to show that, in order to limit the number of photoreceptors in a facet to eight… 
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69 Citations

Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.
TLDR
Analysis of genetic interactions reveals that Fat facets has an additional function later in eye development involving Rap1 and Ras1 proteins, and suggests that undifferentiated cells outside the facet continue to influence facet assembly later inEye development.
The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis.
TLDR
Genetic data support a model whereby Faf removes ubiquitin, a polypeptide tag for protein degradation, from a specific ubiquitinated protein thus preventing its degradation and propose that Liquid facets is a candidate for the critical substrate of Fat facets in the eye.
The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye.
TLDR
Mosaic analysis shows that sdk is required neither in the R cells nor in the extra cell, suggesting that sKD is necessary in the surrounding undifferentiated cells.
Mutagenesis screens for interacting genes reveal three roles for fat facets during Drosophila eye development.
TLDR
Three different eye phenotypes were observed when the fat facets mutants were dominantly enhanced by different mutations, suggesting that fat facets has other functions in addition to its critical role early in eye development.
Genetic analysis of the role of the drosophila fat facets gene in the ubiquitin pathway.
TLDR
The hypothesis that FAT FACETS activity antagonizes that of the proteolytic machinery is supported and the implications for the specificity of FAF and yeast UBPs are discussed.
Determination of Drosophila photoreceptors: timing is everything
TLDR
The possibility that the morphogenetic furrow serves as a moving source of morphogens which supply spatial information to both anterior and posterior tissue, providing temporal cues that regulate the many events involved in orderly assembly of the precise array of retinal cell types in the compound eye is considered.
Identification of Genes That Interact With Drosophila liquid facets
TLDR
Mutagenesis screens of the Drosophila X chromosome and the autosomes for dominant enhancers of the rough eye resulting from overexpression of liquid facets found Mutant alleles of clathrin heavy chain, Rala, split ends, and auxilin were identified as enhancers.
Cell determination strategies in the Drosophila eye.
TLDR
A new model of eye development is described that explains how simple intercellular signals could specify the diverse cell types that constitute the ommatidium.
The deubiquitination enzyme Fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development
Molecular analysis of the klarsicht gene and its role in nuclear migration within differentiating cells of the Drosophila eye
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References

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