Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.

@article{Espinosa2017UndifferentiatedAD,
  title={Undifferentiated and Dedifferentiated Endometrial Carcinomas With POLE Exonuclease Domain Mutations Have a Favorable Prognosis.},
  author={{\'I}{\~n}igo Espinosa and Cheng-Han Lee and Emanuela D'angelo and Jos{\'e} Palacios and Jaime Prat},
  journal={The American journal of surgical pathology},
  year={2017},
  volume={41 8},
  pages={
          1121-1128
        }
}
POLE exonuclease domain mutations have recently been described in undifferentiated endometrial carcinoma but, because of the rarity of this aggressive type of endometrial cancer, their prognostic significance is unknown. We have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, β-catenin, and SMARCB1) and mutational status (POLE, PIK3CA, and PTEN) of 21 undifferentiated carcinomas (8 undifferentiated and 13 dedifferentiated carcinomas). Loss of ARID1A expression was observed in… CONTINUE READING
24
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Rapid progression of disease in two cases of undifferentiated endometrial carcinoma

  • Gynecologic oncology reports
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists

  • International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Endometrial Cancer Presentation and Outcomes Based on Mismatch Repair Protein Expression From a Population-Based Study.

  • International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2016

: clinical outcomes and implications for Lynch syndrome testing

M LeGallo, AJ O’Hara, ML Rudd
  • 2015

POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2015
VIEW 1 EXCERPT

Polymerase epsilon (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome

CC Billingsley, DE Cohn, DG Mutch
  • 2015