Undersulfation of glycosaminoglycans reduces the proliferation of a leukemia cell line in vitro.

@article{AlvarezSilva1996UndersulfationOG,
  title={Undersulfation of glycosaminoglycans reduces the proliferation of a leukemia cell line in vitro.},
  author={M{\'a}rcio Alvarez-Silva and Andr{\'e}a Gonçalves Trentin},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={1996},
  volume={29 9},
  pages={1239-42}
}
Leukemia represents the clonal expansion of an individual cell lineage of the hematopoietic system at a specific point of its maturation and development. This dysregulated expansion of cells is often accompanied by altered adherence to the bone marrow microenvironment and abnormalities in endogenous cytokine production by neoplastic cells. Proteoglycans… CONTINUE READING