Undersulfation of glycosaminoglycans induced by sodium chlorate treatment affects the progression of C6 rat glioma, in-vivo

@article{LoboSoares2007UndersulfationOG,
  title={Undersulfation of glycosaminoglycans induced by sodium chlorate treatment affects the progression of C6 rat glioma, in-vivo},
  author={Bruno Lob{\~a}o-Soares and M{\'a}rcio Alvarez-Silva and Claudia B. N. Mendes de Aguiar and Mauro Nicolau and Andrea Gonçalves Trentin},
  journal={Brain Research},
  year={2007},
  volume={1131},
  pages={29-36}
}
The stimulatory input of extracellular matrix (ECM) components has been implicated in the invasive properties of glioma cells. It has been demonstrated that undersulfation of glycosaminoglycans (GAGs) promoted by sodium chlorate (SC) treatment reduces C6 glioma cell proliferation and adhesion to ECM molecules, in-vitro. In the present study, the authors investigated the involvement of GAG undersulfation in glioma cell growth in the brain parenchyma. The in-vitro treatment of C6 cells with SC… CONTINUE READING