Understanding the transition to seizure by modeling the epileptiform activity of general anesthetic agents.

@article{Liley2005UnderstandingTT,
  title={Understanding the transition to seizure by modeling the epileptiform activity of general anesthetic agents.},
  author={David T. J. Liley and Ingo Bojak},
  journal={Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society},
  year={2005},
  volume={22 5},
  pages={
          300-13
        }
}
A central difficulty in modeling epileptogenesis using biologically plausible computational and mathematical models is not the production of activity characteristic of a seizure, but rather producing it in response to specific and quantifiable physiologic change or pathologic abnormality. This is particularly problematic when it is considered that the pathophysiological genesis of most epilepsies is largely unknown. However, several volatile general anesthetic agents, whose principle targets of… CONTINUE READING
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