Understanding the suicidal brain

  title={Understanding the suicidal brain},
  author={Cornelis van Heeringen and Anamarija Maru{\vs}i{\'c}},
  journal={British Journal of Psychiatry},
  pages={282 - 284}
It has been suggested that the key to preventing suicide is not in the study of the brain, but in the direct study of the human emotions (Shneidman, 1996). However, recent advances in neuroscience are providing support for a theory of human emotions that implicates increasingly well-defined brain 

Neurobiology of Suicidal Behavior. An Integration of Biological and Clinical Findings

This model integrates findings from several perspectives in suicidology and attempts to explain the relationship between various neurobiological, genetic, and clinical observations in suicide research, offering a comprehensive hypothesis to facilitate understanding of this complex outcome.

Functional Brain Imaging of Suicidal Behavior

This chapter reviews the few available studies that have utilized functional neuroimaging, including brain perfusion and receptor ligand studies, and finds that these studies have contributed to the development of the suicidal brain concept.

Is impulsivity a link between childhood abuse and suicide?

Social and Biological Parameters Involved in Suicide Ideation During the COVID-19 Pandemic: A Narrative Review

This review article is intended to provide a comprehensive analysis of suicidal deaths during Covid-19 and addresses the possible link between suicidal ideation and different factors, including psycho-social, behavioral, neurobiological factors (proximal, distal, and inflammatory) and immunity.

Recent alcohol intake and suicidality — a neuropsychological perspective

The authors review the observational and experimental evidence for the acute neuropsychological effects of alcohol intake on suicidal ideation and behaviour and highlight the importance of identifying and tackling acute alcohol intake and binge drinking as a risk factor for suicidal behaviour.

Potential peripheral biological predictors of suicidal behavior in major depressive disorder

Prefrontal cortex dysfunction in patients with suicidal behavior

Investigation of PFC-related neuropsychological function in patients with suicidal behavior found deficits in visuospatial conceptualization, spatial working memory, inhibition, inhibition and visual attention are consistent with prefrontal dysfunction in patientswith suicidal behavior.

Biomarkers of Suicide Risk in Psychosis

Investigation of the long-term suicide risk in schizophrenia spectrum psychosis found attempted suicide was a very important risk factor for suicide in both genders, especially in males, and CSF 5HIAA and HVA concentrations were not associated with suicidal behavior in patients diagnosed with mood disorders.

Biological Prediction of Suicidal Behavior in Patients with Major Depressive Disorder

Despite the high lifetime rate of suicide in patients with major depressive disorder, most never attempt suicide, raising the question of why some people with major depression are at risk of suicide and others are not, and suggests that the predisposition toward suicidal behavior is independent of psychiatric disorders.

Personality Factors Underlying Suicidal Behavior Among Military Youth

Based on results, neuroticism might increase suicide, but extraversion and conscientiousness personality traits are associated with a reduced risk of suicide.



Understanding the neurobiology of emotion perception: implications for psychiatry

  • M. Phillips
  • Psychology, Biology
    British Journal of Psychiatry
  • 2003
There has been increasing interest in the examination of the neurobiological basis of emotion perception in humans and non-human primates, and an acknowledgement that abnormalities in human emotion perception are known.

5 -HT, antidepressant drugs and the psychosocial origins of depression

  • J. Deakin
  • Psychology
    Journal of psychopharmacology
  • 1996
Understanding of what 5-HT normally does seems crucial for a deep understanding of its undoubted role in depression, in the psychosocial origins of depression and in how antidepressant drugs work.

Components of hopelessness about the future in parasuicide

Hopelessness about the future is an important component of depression in general and suicidal behavior in particular. Despite this, little research has examined the concept of hopelessness. A study

A specific attentional bias in suicide attempters.

The attentional bias exhibited by suicidal patients was highly specific, and there was no relation between the bias and measures of anxiety, depression, or hopelessness, whereas suicidal ideation correlated significantly with the attentional biases.

Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide.

Suicide ideation at its worst point: a predictor of eventual suicide in psychiatric outpatients.

The assessment of suicide ideation at its worst point identifies a subgroup of patients at relatively high risk for eventual suicide and robust interventions and periodic monitoring are recommended to reduce long-term suicide risk.

Toward a clinical model of suicidal behavior in psychiatric patients.

A stress-diathesis model is proposed in which the risk for suicidal acts is determined not merely by a psychiatric illness but also by a diathesis, reflected in tendencies to experience more suicidal ideation and to be more impulsive and, therefore, more likely to act on suicidal feelings.

Neuropsychological dysfunction in depressed suicide attempters.

Neuropsychological deficits in depressed patients with high-lethality prior suicide attempts suggest impairment of executive functioning beyond that typically found in major depression.

The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe

Anatomy of the prefrontal cortex chemical neurotransmission animal neuropsychology neurophysiology human neuropsychology neuroimaging overview of prefrontal functions - the temporal organization of