Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease

@article{Hunter2018UnderstandingTR,
  title={Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease},
  author={Sally Hunter and Carol Brayne},
  journal={Molecular Psychiatry},
  year={2018},
  volume={23},
  pages={81-93}
}
Many models of disease progression in Alzheimer’s disease (AD) have been proposed to help guide experimental design and aid the interpretation of results. Models focussing on the genetic evidence include the amyloid cascade (ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), of which the ACH has held a… CONTINUE READING