Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease

@article{Hunter2018UnderstandingTR,
  title={Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease},
  author={Steve Hunter and Carol Brayne},
  journal={Molecular Psychiatry},
  year={2018},
  volume={23},
  pages={81-93}
}
  • Steve Hunter, Carol Brayne
  • Published 2018
  • Medicine
  • Molecular Psychiatry
  • Many models of disease progression in Alzheimer’s disease (AD) have been proposed to help guide experimental design and aid the interpretation of results. Models focussing on the genetic evidence include the amyloid cascade (ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), of which the ACH has held a dominant position for over two decades. However, the ACH has never been fully accepted and has not yet delivered on its therapeutic promise. We… CONTINUE READING

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    Presenilin-1 mutations and Alzheimer’s disease