Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function

  title={Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function},
  author={Daniel Keszthelyi and Freddy J. Troost and Ad A. M. Masclee},
  journal={Neurogastroenterology \& Motility},
Abstract  Tryptophan is the precursor of a wide array of metabolites, which are involved in a variety of aspects of human nutrition and metabolism. Accumulating evidence suggests a role of tryptophan metabolites, especially serotonin (5‐hydroxytryptamin) in intestinal (patho) physiology, although mechanisms of action are still poorly understood. Alterations of serotonin metabolism may give rise to gastrointestinal dysfunction. Recently, it has been postulated that other metabolites of… 

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Endogenous tryptophan metabolism pathways lead to the production of serotonin (5‐hydroxytryptamine; 5‐HT), kynurenine, and several downstream metabolites which are involved in a multitude of

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