Understanding the role of the extracellular matrix in cardiovascular development and disease: where do we go from here?

@article{Lindsey2010UnderstandingTR,
  title={Understanding the role of the extracellular matrix in cardiovascular development and disease: where do we go from here?},
  author={Merry L Lindsey and Thomas Keith Borg},
  journal={Journal of molecular and cellular cardiology},
  year={2010},
  volume={48 3},
  pages={431-2}
}
For many years, analyses of the heart have focused primarily on the role of the myocytes as the principal cell type that generates force. Analyses of the extracellular matrix (ECM) were deemed important, but primarily relevant only in hypertrophy and after myocardial infarction. Related to the ECM was the role of the fibroblast, the principal cell type that makes the ECM. When analyses of the ECM were performed, the focus was primarily on interstitial collagen. This reductionist approach was… CONTINUE READING
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