Understanding the role of SOX9 in acquired diseases: lessons from development.

@article{Pritchett2011UnderstandingTR,
  title={Understanding the role of SOX9 in acquired diseases: lessons from development.},
  author={James Pritchett and Varinder S. Athwal and Neil Roberts and Neil A. Hanley and Karen Piper Hanley},
  journal={Trends in molecular medicine},
  year={2011},
  volume={17 3},
  pages={
          166-74
        }
}
The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder concordant with the expression profile of SOX9 during embryogenesis. The mechanistic understanding of development has revealed roles for SOX9 in regulating cartilage extracellular matrix (ECM) production and cell proliferation, among others. More recently, it transpires that SOX9 becomes expressed and induces destructive ECM components in… CONTINUE READING

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