Understanding the role of DISC1 in psychiatric disease and during normal development.

@article{Brandon2009UnderstandingTR,
  title={Understanding the role of DISC1 in psychiatric disease and during normal development.},
  author={Nicholas J. Brandon and Jessica K Millar and Carsten Korth and Hazel L. Sive and Karun K Singh and Akira Sawa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 41},
  pages={12768-75}
}
The biology of schizophrenia is complex with multiple hypotheses (dopamine, glutamate, neurodevelopmental) well supported to underlie the disease. Pathways centered on the risk factor "disrupted in schizophrenia 1" (DISC1) may be able to explain and unite these disparate hypotheses and will be the topic of this mini-symposium preview. Nearly a decade after its original identification at the center of a translocation breakpoint in a large Scottish family that was associated with major… CONTINUE READING

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