Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies.

@article{Gui2007UnderstandingTR,
  title={Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies.},
  author={Chunshan Gui and Weiliang Zhu and Gang Chen and Xiaomin Luo and Oi Wah Liew and Chum Mok Puah and K. A. Chen and Hualiang Jiang},
  journal={Proteins},
  year={2007},
  volume={67 1},
  pages={41-52}
}
Platelet-activating factor receptor (PAFR) is a member of G-protein coupled receptor (GPCR) superfamily. Understanding the regulation mechanisms of PAFR by its agonists and antagonists at the atomic level is essential for designing PAFR antagonists as drug candidates for treating PAF-mediated diseases. In this study, a 3D model of PAFR was constructed by a hierarchical approach integrating homology modeling, molecular docking and molecular dynamics (MD) simulations. Based on the 3D model… CONTINUE READING

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