Understanding the poor iontophoretic transport of lysozyme across the skin: when high charge and high electrophoretic mobility are not enough.

@article{Dubey2014UnderstandingTP,
  title={Understanding the poor iontophoretic transport of lysozyme across the skin: when high charge and high electrophoretic mobility are not enough.},
  author={Sachin Dubey and Yogeshvar N Kalia},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={183},
  pages={
          35-42
        }
}
The original aim of the study was to investigate the transdermal iontophoretic delivery of lysozyme and to gain further insight into the factors controlling protein electrotransport. Initial experiments were done using porcine skin. Lysozyme transport was quantified by using an activity assay based on the lysis of Micrococcus lysodeikticus and was corrected for the release of endogenous enzyme from the skin during current application. Cumulative iontophoretic permeation of lysozyme during 8h at… CONTINUE READING
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