Understanding the molecular mechanism of blood–brain barrier damage in an experimental model of Japanese encephalitis: Correlation with minocycline administration as a therapeutic agent

@article{Mishra2009UnderstandingTM,
  title={Understanding the molecular mechanism of blood–brain barrier damage in an experimental model of Japanese encephalitis: Correlation with minocycline administration as a therapeutic agent},
  author={M. Mishra and K. Dutta and Shaik Khaleelulla Saheb and A. Basu},
  journal={Neurochemistry International},
  year={2009},
  volume={55},
  pages={717-723}
}
  • M. Mishra, K. Dutta, +1 author A. Basu
  • Published 2009
  • Medicine, Biology
  • Neurochemistry International
  • The blood-brain barrier (BBB) serves to protect the central nervous system (CNS) from damage by exogenous molecules. Japanese encephalitis (JE), caused by a neurotropic flavivirus, leads to inflammation in the CNS, neuronal death and also compromises the structural and functional integrity of the BBB. Minocycline, a semisynthetic tetracycline, has been found to be broadly protective in neurological disease models featuring inflammation and cell death and at present, is being evaluated in… CONTINUE READING

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