Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

@article{Woolley2017UnderstandingTM,
  title={Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach},
  author={Michael J. Woolley and J. Simms and J. C. Mobarec and C. A. Reynolds and A. Conner},
  journal={Molecular and Cellular Endocrinology},
  year={2017},
  volume={454},
  pages={39-49}
}
  • Michael J. Woolley, J. Simms, +2 authors A. Conner
  • Published 2017
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The extracellular loop 2 (ECL2) region is the most conserved of the three ECL domains in family B G protein-coupled receptors (GPCRs) and has a fundamental role in ligand binding and activation across the receptor super-family. ECL2 is fundamental for ligand-induced activation of the calcitonin gene related peptide (CGRP) receptor, a family B GPCR implicated in migraine and heart disease. In this study we apply a comprehensive targeted non-alanine substitution analysis method and molecular… CONTINUE READING
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