Understanding the molecular basis of stability in Kunitz (STI) family of inhibitors in terms of a conserved core tryptophan residue: A theoretical investigation.

Abstract

β-trefoil is one of the superfolds among proteins. Important classes of proteins like Interleukins (ILs), FibroblastGrowth Factors (FGFs), Kunitz (STI) family of inhibitors etc. belong to this fold. Kunitz (STI) family of inhibitors of proteins possess a highly conserved and structurally important Trytophan 91 (W91) residue, which stitches the top layer of… (More)
DOI: 10.1016/j.jmgm.2017.05.018

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Cite this paper

@article{Sharma2017UnderstandingTM, title={Understanding the molecular basis of stability in Kunitz (STI) family of inhibitors in terms of a conserved core tryptophan residue: A theoretical investigation.}, author={Ravi Datta Sharma and Nabajyoti Goswami and Debasree Ghosh and Sudip Majumder}, journal={Journal of molecular graphics & modelling}, year={2017}, volume={75}, pages={233-240} }