Corpus ID: 41301821

Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis.

@article{Tian2007UnderstandingTM,
  title={Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis.},
  author={H. Tian and B. Cronstein},
  journal={Bulletin of the NYU hospital for joint diseases},
  year={2007},
  volume={65 3},
  pages={
          168-73
        }
}
Methotrexate has been widely used for the treatment of rheumatoid arthritis (RA). The mechanisms of action of methotrexate are complex. Developed as a folic acid analogue, methotrexate inhibits purine and pyrimidine synthesis, which accounts for its efficacy in the therapy of cancer as well as for some of its toxicities. Recently, many studies have focused on the adenosine-mediated antiinflammatory effects of methotrexate. Certain aspects of methotrexate toxicities are also attributed to… Expand
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