Understanding the mechanisms and drivers of antimicrobial resistance

@article{Holmes2016UnderstandingTM,
  title={Understanding the mechanisms and drivers of antimicrobial resistance},
  author={Alison H. Holmes and Luke S.P. Moore and Arnfinn Sundsfjord and Martin Steinbakk and Laura J. V. Piddock},
  journal={The Lancet},
  year={2016},
  volume={387},
  pages={176-187}
}

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References

SHOWING 1-10 OF 110 REFERENCES

Spread of resistant bacteria and resistance genes from animals to humans--the public health consequences.

  • K. Mølbak
  • Medicine, Biology
    Journal of veterinary medicine. B, Infectious diseases and veterinary public health
  • 2004
The paper reviews the lines of evidence which link the use of antimicrobial drugs for food animals with the emergence of antimicrobial drug resistance in bacteria pathogenic to humans, with a

The role of antibiotics and antibiotic resistance in nature.

  • R. Aminov
  • Biology, Medicine
    Environmental microbiology
  • 2009
A broader overview of the role of antibiotics and antibiotic resistance in nature from the evolutionary and ecological prospective suggests that antibiotics have evolved as another way of intra- and inter-domain communication in various ecosystems.

Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains

It is found that a combined intervention strategy can limit nosocomial outbreaks, even when vaccine efficacy is imperfect and the broader utility of vaccine-based resistance control strategies should be further explored taking into account population structure, and the resistance and transmission patterns of the pathogen.

Antibiotic resistance-the need for global solutions.

Persistence of Transferable Extended-Spectrum-β-Lactamase Resistance in the Absence of Antibiotic Pressure

Carriage of pCT was found to impose no detectable fitness cost on various bacterial hosts and an absence of antibiotic pressure and inactivation of the antibiotic resistance gene also had no effect on plasmid persistence, conjugation frequency, or bacterial-host biology.

Targeting Imperfect Vaccines against Drug-Resistance Determinants: A Strategy for Countering the Rise of Drug Resistance

It is shown that the population-wide impact of such vaccines depends on the additional effect on resistant strains and on the overall effect (against all strains) of the vaccine, and resistance-conferring accessory gene products or resistant alleles of essential genes could be valuable as components of vaccines even if their specific protective effect is weak.
...