Understanding the mechanism of action of B12-dependent ethanolamine ammonia-lyase: synergistic interactions at play.

Abstract

Ab initio molecular orbital calculations are used to examine the mechanism of action of B(12)-dependent ethanolamine ammonia-lyase involving the conversion of 2-aminoethanol to acetaldehyde plus ammonia. We attempt to elucidate the mechanism by which the enzyme facilitates this reaction through interactions between active-site residues and the substrate… (More)

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