Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems.

@article{NGoma2012UnderstandingTL,
  title={Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems.},
  author={Jean-Claude Bakala N'Goma and Sawsan Amara and Kaouthar Dridi and Vincent Jannin and Fr{\'e}d{\'e}ric Carri{\`e}re},
  journal={Therapeutic delivery},
  year={2012},
  volume={3 1},
  pages={
          105-24
        }
}
Many of the compounds present in lipid-based drug-delivery systems are esters, such as acylglycerols, phospholipids, polyethyleneglycol mono- and di-esters and polysorbate, which can be hydrolyzed by the various lipolytic enzymes present in the GI tract. Lipolysis of these compounds, along with dietary fats, affects the solubility, dispersion and bioavailibity of poorly water-soluble drugs. Pharmaceutical scientists have been taking a new interest in fat digestion in this context, and several… CONTINUE READING

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