Understanding the limitations of radiation-induced cell cycle checkpoints

  title={Understanding the limitations of radiation-induced cell cycle checkpoints},
  author={Dorothee Deckbar and Penny A Jeggo and Markus Lobrich},
  booktitle={Critical reviews in biochemistry and molecular biology},
The DNA damage response pathways involve processes of double-strand break (DSB) repair and cell cycle checkpoint control to prevent or limit entry into S phase or mitosis in the presence of unrepaired damage. Checkpoints can function to permanently remove damaged cells from the actively proliferating population but can also halt the cell cycle temporarily to provide time for the repair of DSBs. Although efficient in their ability to limit genomic instability, checkpoints are not foolproof but… CONTINUE READING
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