Understanding the key factors that control the rate of-hairpin folding

  title={Understanding the key factors that control the rate of-hairpin folding},
  author={Deguo Du and Yongjin Zhu and C. Huang and Feng Gai},
Both turn sequence and interstrand hydrophobic side-chain–sidechain interaction have been suggested to be important determinants of -hairpin stability. However, their roles in controlling the folding dynamics of -hairpins have not been clearly determined. Herein, we investigated the structural stability and folding kinetics of a series of tryptophan zippers by static IR and CD spectroscopies and the IR temperature jump method. Our results support a -hairpin folding mechanism wherein the rate… CONTINUE READING


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