Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases.

@article{Upadya2014UnderstandingTI,
  title={Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases.},
  author={Megha Haridas Upadya and Jude Juventus Aweya and Yee Joo Tan},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 11},
  pages={2913-26}
}
The current therapeutic regimen to combat chronic hepatitis C is not optimal due to substantial side effects and the failure of a significant proportion of patients to achieve a sustained virological response. Recently developed direct-acting antivirals targeting hepatitis C virus (HCV) enzymes reportedly increase the virologic response to therapy but may lead to a selection of drug-resistant variants. Besides direct-acting antivirals, another promising class of HCV drugs in development include… CONTINUE READING