Understanding the functional roles of amino acid residues in enzyme catalysis.

  title={Understanding the functional roles of amino acid residues in enzyme catalysis.},
  author={Gemma L. Holliday and John B. O. Mitchell and Janet M. Thornton},
  journal={Journal of molecular biology},
  volume={390 3},
The MACiE database contains 223 distinct step-wise enzyme reaction mechanisms and holds representatives from each EC sub-subclass where there is a crystal structure and sufficient evidence in the literature to support a mechanism. Each catalytic step of every reaction sequence in MACiE is fully annotated so that it includes the function of the catalytic residues involved in the reaction and the mechanism by which substrates are transformed into products. Using MACiE as a knowledge base, we have… CONTINUE READING


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