Understanding the folding mechanism of an alpha-helical hairpin.

  title={Understanding the folding mechanism of an alpha-helical hairpin.},
  author={Deguo Du and Feng Gai},
  volume={45 44},
The alpha-helical hairpin is the fundamental building block of the widespread helix-turn-helix DNA binding motif. With two antiparallel helices connected by a reverse turn, the alpha-helical hairpin structure may be regarded as a "supersecondary structural element" and, therefore, could exhibit rather unique folding properties. So far, the folding mechanism of alpha-helical hairpins has not been studied in detail and remains elusive. Herein, we examine the effects of the turn, the hydrophobic… CONTINUE READING

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