Understanding the effect of lactose particle size on the properties of DPI formulations using experimental design.

@article{Guenette2009UnderstandingTE,
  title={Understanding the effect of lactose particle size on the properties of DPI formulations using experimental design.},
  author={Estelle Guenette and Andrew P. Barrett and Debbie Kraus and Rachel I. Brody and Ljiljana J Harding and Gavin Magee},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={380 1-2},
  pages={80-8}
}
Medicines for delivering therapeutic agents to the lung as dry powders primarily consist of a carrier and a micronised active pharmaceutical ingredient (API). The performance of an inhaled formulation will depend on a number of factors amongst which the particle size distribution (PSD) plays a key role. It is suggested that increasing the number of fine particles in the carrier can improve the aerosolisation of the API. In addition the effect of PSD upon a bulk powder is also broadly understood… CONTINUE READING