Understanding the degradation pathway of a poorly water-soluble drug formulated in PEG-400.

@article{Kochling2007UnderstandingTD,
  title={Understanding the degradation pathway of a poorly water-soluble drug formulated in PEG-400.},
  author={Jianmei D Kochling and Hai Miao and Christopher R. Young and Adam R Looker and Michael Wayne Shannon and Eda Ross Montgomery},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2007},
  volume={43 5},
  pages={1638-46}
}
VX-497 is a poorly water-soluble compound. It is formulated in PEG-400 and encapsulated in softgel capsules. Although the drug product is stable at refrigerated conditions, many degradation peaks have been observed at accelerated storage conditions. An investigation utilizing high performance liquid chromatography-mass spectrometry (HPLC-MS) was conducted to understand the degradation mechanism of the active pharmaceutical ingredient (VX-497) in PEG-400 formulation. Results revealed that the… CONTINUE READING

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