Understanding the course of Peyronie's disease

@article{Garaffa2013UnderstandingTC,
  title={Understanding the course of Peyronie's disease},
  author={G. Garaffa and L. Trost and E. Serefoglu and D. Ralph and W. Hellstrom},
  journal={International Journal of Clinical Practice},
  year={2013},
  volume={67}
}
To correct common misconceptions about Peyronie's disease (PD) that present obstacles to early recognition and treatment. 
Symptoms, Their Physiopathology, and Outpatient Clinical Practice and Diagnosis
Peyronie’s disease (PD) is a segmentary or diffused fibrosis characterized by the appearance of inflammatory plaques with formation of palpable plaques in the tunica albuginea of the penis, locatedExpand
Natural History of Peyronie’s Disease
TLDR
This chapter focuses mainly on the most important studies on the natural history of Peyronie’s disease, which have demonstrated that PD is a progressive disease process and that untreated PD patients generally improve spontaneously. Expand
The Natural History of Peyronie's Disease
TLDR
This review provides a detailed overview of natural history of PD, specifically focusing on clinical manifestations and the underlying molecular regulation patterns, and concludes that better understanding of the molecular pathophysiology of this condition remains paramount towards an in-depth comprehension of the disorder and the development of newer and more effective disease-targeted interventions. Expand
All about Peyronie's disease
Peyronie's disease (PD) is an acquired connective tissue disorder of the tunica albuginea of the corpus cavernosum, characterized by excessive fibrosis and plaque formation. PD can result inExpand
Collagenase clostridium histolyticum: a novel medical treatment for Peyronie's disease.
TLDR
CCH is the gold standard non-surgical option in the management of PD and a new modified shortened protocol is suggested that will reduce the cost and duration of treatment without compromising the safety or efficacy of treatment. Expand
NON-SURGICAL TREATMENT OF PEYRONIE'S DISEASE: A COMPREHENSIVE REVIEW.
TLDR
This review article focuses on conservative treatment options, topical, intralesional therapy, traction and vacuum therapy, and scientific articles relating to pharmacologic data in men with Peyronie's disease. Expand
Molecular Mechanisms and Current Pharmacotherapy of Peyronie’s Disease: A Review
TLDR
The molecular mechanisms and pharmacotherapies ofeyronie’s disease are summarized and more attention should be given simultaneously to epigenetic changes, inflammatory cytokines, the abnormal wound-healing process, and profibrotic and anti-f fibrotic factors to provide more options for this refractory disease. Expand
Changes in the Effects of Peyronie's Disease After Treatment With Collagenase Clostridium histolyticum: Male Patients and Their Female Partners
TLDR
The results support the safety and efficacy of CCH in the management of appropriate patients with PD and the potential benefits for patients' partners. Expand
Surgical Management of Peyronie’s Disease
TLDR
A review of the disease process, preoperative evaluation, operative planning, surgical treatments with outcomes and complications, and nascent developments in surgical management and graft development is presented. Expand
New insights into the pathogenesis of Peyronie’s disease: A narrative review
TLDR
New insights are provided into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathways, biochemical mechanisms, genetic factors responsible for fibrogenesis, and intracellular signal cascades. Expand
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References

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The prevalence of Peyronie's disease: results of a large survey
Objectives To determine the prevalence of Peyronie's disease, a localized connective tissue disorder of the penile tunica albuginea, the symptoms of which include palpable plaque, painful erectionsExpand
Diabetes mellitus is associated with severe Peyronie’s disease
To evaluate the severity of penile deformity and penile blood flow variables in men with Peyronie’s disease (PD) and diabetes mellitus (DM), and those with no risk factors.
Peyronie's Disease.
Peyronie's disease is a psychologically and physically devastating disorder that is manifest by a fibrous inelastic scar of the tunica albuginea, resulting in palpable penile scar in the flaccidExpand
The association between Peyronie's and Dupuytren's disease
TLDR
Investigation of the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics found 28 men reported to have one or more first or second degree relatives with DD. Expand
Peyronie's disease (CME).
TLDR
PyD does not invariably progress to a complete loss of the ability for sexual intercourse; indeed, using one or more of the treatment approaches outlined can, in most cases, result in adequate restoration of sexual function. Expand
The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease
Study Type – Therapy (case series)
Level of Evidence 4
New discoveries in the basic science understanding of Peyronie’s disease
TLDR
Differential gene expression studies have identified candidate up-regulated or down-regulated genes that are involved in the pathophysiology of Peyronie’s disease. Expand
The management of Peyronie's disease: evidence-based 2010 guidelines.
TLDR
The real etiology of Peyronie's disease and the mechanisms of formation of the plaque still remain obscure, and conservative management is obtaining a progressively larger consensus among the experts. Expand
The medical management of Peyronie's disease
TLDR
In this Review, the current medical treatment options available for the management of Peyronie's disease are discussed and a management algorithm is proposed. Expand
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