Understanding the congener-specific toxicity in polychlorinated dibenzo-p-dioxins: chlorination pattern and molecular quadrupole moment.

@article{Mhin2002UnderstandingTC,
  title={Understanding the congener-specific toxicity in polychlorinated dibenzo-p-dioxins: chlorination pattern and molecular quadrupole moment.},
  author={Byung Jin Mhin and Jung Eun Lee and Wonyong Choi},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 1},
  pages={144-8}
}
It is well known that the biological activities and toxicities of planar polychlorinated aromatic compounds are extremely sensitive to chlorination pattern. Although their toxic responses have been correlated with the relative affinity for the receptor, the origin of this congener specificity is not well understood. We present a general interpretation of the congener-specific activity in polychlorinated dibenzo-p-dioxins, which concludes that molecular electrostatics is the principal factor… CONTINUE READING