Understanding the concentration dependence of viral capsid assembly kinetics--the origin of the lag time and identifying the critical nucleus size.

@article{Hagan2010UnderstandingTC,
  title={Understanding the concentration dependence of viral capsid assembly kinetics--the origin of the lag time and identifying the critical nucleus size.},
  author={Michael F. Hagan and Oren M Elrad},
  journal={Biophysical journal},
  year={2010},
  volume={98 6},
  pages={1065-74}
}
The kinetics for the assembly of viral proteins into a population of capsids can be measured in vitro with size exclusion chromatography or dynamic light scattering, but extracting mechanistic information from these studies is challenging. For example, it is not straightforward to determine the critical nucleus size or the elongation time (the time required for a nucleus to grow to completion). In this work, we study theoretical and computational models for capsid assembly to show that the… CONTINUE READING