Understanding the characteristics of mass spectrometry data through the use of simulation

@article{Coombes2005UnderstandingTC,
  title={Understanding the characteristics of mass spectrometry data through the use of simulation},
  author={Kevin R. Coombes and John M Koomen and Keith A. Baggerly and Jeffrey S. Morris and Ryuji Kobayashi},
  journal={Cancer Informatics},
  year={2005},
  volume={1},
  pages={41 - 52}
}
BACKGROUND Mass spectrometry is actively being used to discover disease-related proteomic patterns in complex mixtures of proteins derived from tissue samples or from easily obtained biological fluids. The potential importance of these clinical applications has made the development of better methods for processing and analyzing the data an active area of research. It is, however, difficult to determine which methods are better without knowing the true biochemical composition of the samples used… CONTINUE READING
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