Understanding the cause of sporadic Alzheimer's disease.

  title={Understanding the cause of sporadic Alzheimer's disease.},
  author={Henrik Zetterberg and Niklas Mattsson},
  journal={Expert review of neurotherapeutics},
  volume={14 6},
The increasing prevalence of Alzheimer's disease (AD) and a lack of effective prevention or disease-modifying therapies are global challenges with devastating personal, social and economic consequences. The amyloid β (Aβ) hypothesis posits that cerebral β-amyloidosis is a critical early event in AD pathogenesis. However, failed clinical trials of Aβ-centric drug candidates have called this hypothesis into question. Whereas we acknowledge that the Aβ hypothesis is far from disproven, we here re… CONTINUE READING
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