Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets.

@article{Harrison2014UnderstandingTB,
  title={Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets.},
  author={Ian P. Harrison and Stavros Selemidis},
  journal={Clinical and experimental pharmacology & physiology},
  year={2014},
  volume={41 8},
  pages={
          533-42
        }
}
Reactive oxygen species (ROS), the cellular products of myriad physiological processes, have long been understood to lead to cellular damage if produced in excess and to be a causative factor in cancer through the oxidation and nitration of various macromolecules. Reactive oxygen species influence various hallmarks of cancer, such as cellular proliferation and angiogenesis, through the promotion of cell signalling pathways intrinsic to these processes and can also regulate the function of key… CONTINUE READING

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