Understanding the association of stem cells in fetal development and carcinogenesis during pregnancy

  title={Understanding the association of stem cells in fetal development and carcinogenesis during pregnancy},
  author={Kasturi Banerjee and Agnibha Chattopadhyay and Satarupa Banerjee},
  journal={Advances in Cancer Biology - Metastasis},



Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia

It is reported that Notch1 upregulation in T‐ALL induced a change in the metabolism of the important amino acid glutamine, preventing glutamine synthesis through the downregulation of glutamine synthetase (GS), and the combined treatment targeting mTORC1 and limiting glutamine availability had a synergistic effect to induce apoptosis and to prevent notch1‐driven leukemia progression.

Exosomal microRNA‐139‐5p from mesenchymal stem cells accelerates trophoblast cell invasion and migration by motivation of the ERK/MMP‐2 pathway via downregulation of protein tyrosine phosphatase

This work has assessed the specific mechanism of mesenchymal stem cells (MSC)‐originated exosomes in PE and its role in systemic dysfunctions, including preeclampsia.

Role of CD133 in human embryonic stem cell proliferation and teratoma formation

The data imply that CD133 could be an additional target and used as a selective marker to sort and eliminate undifferentiated cells in reducing potential teratoma formation risk of hESCs in regenerative medicine.

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.

It is proposed that timed cell-intrinsic or niche-focused metabolic disruption can exploit a transient vulnerability and induce metabolic collapse in cancer cells to overcome chemoresistance.

Pregnancy and Cancer: the INCIP Project

Further international research is needed to provide patients diagnosed with cancer during pregnancy with the best individualized management plan to optimize obstetrical and oncological care.

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

An overview on the therapeutic application of MSCs for regenerative medicine and the processes that orchestrates tissue repair, with a special emphasis placed on cancer, including central nervous system tumors is provided.

A potential new mechanism for pregnancy loss: considering the role of LINE-1 retrotransposons in early spontaneous miscarriage

It is predicted that reduced suppression of L 1s in germ cells or early-stage embryos may lead to excessive genome mutation by retrotransposon insertion, or to the induction of an inflammatory response or apoptosis due to increased expression of L1-derived nucleic acids and proteins, and so disrupt gene function important for embryogenesis.

New aspects of amino acid metabolism in cancer

This review discusses the stromal/cancer cell relationship, by using examples to illustrate a number of different ways in which cancer cells can rely on and contribute to their microenvironment – both as a stable network and in response to therapy.