Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection

@article{Yates2007UnderstandingTS,
  title={Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection},
  author={A. Yates and Jaroslav Stark and Nigel Klein and Rustom Antia and Robin Callard},
  journal={PLoS Medicine},
  year={2007},
  volume={4},
  pages={95 - 98}
}
BACKGROUND The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood. One potential explanation is that the low average rate of homeostatic proliferation or immune activation dictates the pace of a "runaway" decline of memory CD4(+) T cells, in which activation drives infection, higher viral loads, more recruitment of cells into an activated state, and further infection events. We explore this… CONTINUE READING

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