Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition

  title={Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition},
  author={Mathieu Dondelinger and Patrice Fil{\'e}e and Eric Sauvage and Birgit Quinting and Serge Muyldermans and Moreno Galleni and Maryl{\'e}ne Vandevenne},
  journal={Frontiers in Immunology},
Monoclonal antibodies are playing an increasing role in both human and animal health. Different strategies of protein and chemical engineering, including humanization techniques of non-human antibodies were applied successfully to optimize clinical performances of antibodies. Despite the emergence of techniques allowing the development of fully human antibodies such as transgenic Xeno-mice, antibody humanization remains a standard procedure for therapeutic antibodies. An important prerequisite… 

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