Optimization of Skin Moisturizer Formula Based on Fixed Oil (VCO, Olive Oil, and Jojoba Oil)
- Journal of Pharmacy and Science
Currently, formulations of skin moisturizers are derived from natural compounds. Fixed oils are known to have compounds that potential to be developed as skin moisturizers based on emollient…
Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- MedicineClinical, cosmetic and investigational dermatology
Ceramide cream increases skin hydration and improves barrier function which may make it suitable for use on dry skin.
Performance and Tolerability of the Moisturizers Cetaphil® and Excipial® in Atopic Dermatitis: What is the Evidence Based on Randomized Trials?
- PsychologyDermatology and Therapy
The results from four randomized controlled studies examining these moisturizers are in line with those of the Cochrane Review that moisturizers themselves have beneficial effects, and that combining moisturizers with active topical treatment produced better results when compared toactive topical treatment alone.
A daily regimen of a ceramide‐dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial
- MedicineDermatologic therapy
The ceramide‐dominant physiological lipid‐based moisturizing cream and cleanser safely restores skin permeability and improves the signs and symptoms of eczema in adults.
Stratum Corneum Structure and Function Studied by X-ray Diffraction
X-ray diffraction is one of the powerful tools in the study of a variety of structures in the stratum corneum at the molecular level. Resolving structural modifications during functioning is an…
Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease
- Medicine, BiologyJournal of diabetes
Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2abetes and its associated cutaneous disorders.
Physiological, Pathological, and Circadian Factors Impacting Skin Hydration
A multiplicity of interacting processes among these parameters, ultimately impacting skin hydration in normal skin and playing a role in conditions such as atopic dermatitis and psoriasis, are indicated.
Thermally damaged porcine skin is not a surrogate mechanical model of human skin
- BiologyScientific reports
Multivariate classification involving the five mechanical properties using logistic regression can successfully separate the two skin types with a classification accuracy exceeding 95% for each loading rate individually as well as combined.
Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids
The main objective of this review is to establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment.
Depth‐dependent hydration dynamics in human skin: Vehicle‐controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near‐infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception
- MedicineSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
This study evaluated the efficacy of an NMF‐enriched moisturizer containing 10% urea on different aspects of SC hydration of dry skin.
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Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema.
- BiologyThe Journal of investigative dermatology
Dry skin in the elderly: complexities of a common problem.
- MedicineClinics in dermatology
Factors which influence the water content of the stratum corneum.
- Medicine, ChemistryThe Journal of investigative dermatology
It is apparent that the water content of the cornified epithelium is a more important factor in maintaining the flexibility of this layer than is its oil content.
Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum.
- BiologyThe Journal of investigative dermatology
It is hypothesized that carriers of FLG-null mutations have reduced level of NMF in the SC, as filaggrin is the precursor protein for the amino-acid-derived components of the NMF.
[Topically applied arginine hydrochloride. Effect on urea content of stratum corneum and skin hydration in atopic eczema and skin aging].
- MedicineDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
The urea deficit in the stratum corneum in atopic dermatitis and elderly skin was corrected not by applying the moisturizer urea itself but instead by using arginine - its precursor in the Krebs-Henseleit urea cycle.
Effects of aging and xerosis on the amino acid composition of human skin.
- Chemistry, MedicineThe Journal of investigative dermatology
The effect of aging on the amino acid contents of skin samples from young and old subjects and from age-matched donors with dry skin syndrome was more pronounced than the effect of xerosis.
Skin hydration: a review on its molecular mechanisms
- BiologyJournal of cosmetic dermatology
The discovery of the existence of the water‐transporting protein aquaporin‐3 in the viable epidermis and the presence of tight junction structures at the junction between the stratum granulosum and SC have brought new insights into the mechanisms of skin water distribution and barrier function.
The management of dry skin with topical emollients – recent perspectives
- MedicineJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
The constituent ingredients of emollients should address the different factors that contribute to dry skin and attempt to restore epidermal differentiation, to help to restore the lipid lamellae, improve skin hydration, skin elasticity and prevent itching.
Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders
- MedicineAmerican journal of clinical dermatology
In double-blind studies moisturizers with urea have been shown to reduce TEWL in atopic and ichthyotic patients and ceramide-dominant lipid mixture improved atopic dermatitis and decreased transepidermal water loss in an open-label study in children.