Understanding the Process of Fibrosis in Duchenne Muscular Dystrophy

  title={Understanding the Process of Fibrosis in Duchenne Muscular Dystrophy},
  author={Yacine Kharraz and Joana Guerra and Patrizia Pessina and Antonio Serrano and Pura Mu{\~n}oz-C{\'a}noves},
  booktitle={BioMed research international},
Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue healing leading to loss of its architecture and function. Fibrotic diseases are often associated with chronic pathologies and occur in a large variety of vital organs and tissues, including skeletal muscle. In human muscle, fibrosis is most readily associated with the severe muscle wasting disorder Duchenne muscular dystrophy (DMD), caused by loss of dystrophin gene function. In DMD, skeletal muscle… CONTINUE READING