Understanding the Placebo Effect: Contributions from Neuroimaging

  title={Understanding the Placebo Effect: Contributions from Neuroimaging},
  author={Sarah C. Lidstone and A. Jon Stoessl},
  journal={Molecular Imaging and Biology},
Neuroimaging studies have provided a major contribution to our understanding of the mechanisms of the placebo effect in neurological and psychiatric disorders. Expectation of symptom improvement has long been believed to play a critical role in the placebo effect, and is associated with increased endogenous striatal dopamine release in Parkinson’s disease and increased endogenous opioid transmission in placebo analgesia. Evidence from positron emission tomography and functional magnetic… 
Toward understanding the placebo effect: investigating a possible retrocausal factor.
  • D. RadinE. Lobach
  • Psychology, Biology
    Journal of alternative and complementary medicine
  • 2007
It is suggested that comprehensive models seeking to explain placebo effects, and in general how expectation affects the mind and body, may require consideration of retrocausal influences.
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The placebo effect in neurological disorders
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
In vivo evidence is provided for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo, indicating that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.
Brain Activity Associated with Expectancy-Enhanced Placebo Analgesia as Measured by Functional Magnetic Resonance Imaging
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Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of μ-opioid receptor signaling in the human brain.
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