Genetics of longevity in model organisms: debates and paradigm shifts.
- BiologyAnnual review of physiology
Central concepts about the nature of aging are reexamine, including the hyperfunction theory, which postulates that processes contributing to growth and reproduction run on in later life, leading to hypertrophic and hyperplastic pathologies.
Genomes optimize reproduction: aging as a consequence of the developmental program.
The developmental theory of aging is reviewed, revive, and refine, and it is suggested that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals.
Bacterial aging: from mechanistic basis to evolutionary perspective
- BiologyCellular and Molecular Life Sciences
In this paper, the current view on the mechanistic background and evolutionary significance of bacterial kind of aging is presented, with particular emphasis on the role of asymmetric cell division, the characteristics of stationary growth phase, and therole of oxidative protein damage.
The hyperfunction theory: An emerging paradigm for the biology of aging Ageing Research Reviews
Here ideas about AP and programmatic aging are reviewed, particularly those of M.V. Blagosklonny (the hyperfunction theory) and J.P. de Magalh ˜ aes (the developmental theory), and their capacity to make sense of diverse experimental findings is assessed.
Aging: Evolutionary Theory Meets Genomic Approaches
The evolution of the aging field over the past several years and the implications of the move toward genomics are reviewed, including the scope of cellular processes that influence longevity and the conservation of longevity determinants between organisms are reviewed.
Comparative Genomics of Aging
The results of a direct comparison of spontaneous DNA mutation frequencies in somatic tissue of mice and fruit flies using transgenic mutational reporter genes are reviewed.
The hyperfunction theory: an emerging paradigm for the biology of aging
- BiologyAgeing Research Reviews
DNA damage and ageing: new-age ideas for an age-old problem
- BiologyNature Cell Biology
Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.
SHOWING 1-10 OF 86 REFERENCES
Mechanisms of aging: public or private?
- BiologyNature Reviews Genetics
Evidence is mounting that modulators of the rate of ageing are conserved over large evolutionary distances, and this conservation might stem from mechanisms that match reproductive rate to nutrient supply.
Aging and Genome Maintenance: Lessons from the Mouse?
The use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans is discussed.
Optimally, mutation and the evolution of ageing
Evidence for the importance of both selection against late-acting mutations and selection against deleterious mutations is emerging, and unravelling their relative importance presents experimentalists with a major challenge.
The evolution of ageing and longevity
- BiologyProceedings of the Royal Society of London. Series B. Biological Sciences
This ‘disposable soma’ theory of the evolution of ageing also proposes that a high level of accuracy is maintained in immortal germ line cells, or alternatively, that any defective germ cells are eliminated.
Aging, tumor suppression and cancer: high wire-act!
- BiologyMechanisms of Ageing and Development
Replicative senescence and the art of counting.
- BiologyExperimental gerontology
Data are reviewed that show that telomeres, the major clock identified in human cells so far, do in fact measure stress and damage accumulation much more than simple mitotic time.
Fitness cost of extended lifespan in Caenorhabditis elegans
- BiologyProceedings of the Royal Society of London. Series B: Biological Sciences
It is demonstrated by laboratory natural selection that partial loss of function of the insulin receptor–like protein DAF–2 results in dramatically reduced fitness even under laboratory conditions, consistent with an evolutionary theory of aging.
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Strong evidence is found that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals.
Genetic pathways that regulate ageing in model organisms
Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.