Understanding the Mechanisms Controlling Leishmania amazonensis Infection In Vitro: The Role of LTB4 Derived From Human Neutrophils

@inproceedings{Tavares2014UnderstandingTM,
  title={Understanding the Mechanisms Controlling Leishmania amazonensis Infection In Vitro: The Role of LTB4 Derived From Human Neutrophils},
  author={Natalia Machado Tavares and Th{\'e}o Ara{\'u}jo-Santos and Lilian G. Afonso and Paula Monalisa Nogueira and Ulisses Gazos Lopes and Rodrigo P Soares and Patr{\'i}cia Torres Bozza and Christianne Bandeira-Melo and Val{\'e}ria Matos Borges and Cl{\'a}udia Ida Brodskyn},
  booktitle={The Journal of infectious diseases},
  year={2014}
}
Neutrophils are rapidly recruited to the site of Leishmania infection and play an active role in capturing and killing parasites. They are the main source of leukotriene B4 (LTB4), a potent proinflammatory lipid mediator. However, the role of LTB4 in neutrophil infection by Leishmania amazonensis is not clear. In this study, we show that L. amazonensis or its lipophosphoglycan can induce neutrophil activation, degranulation, and LTB4 production. Using pharmacological inhibitors of leukotriene… CONTINUE READING