Understanding the Cost-Effectiveness of Influenza Vaccination in Children: Methodological Choices and Seasonal Variability

  title={Understanding the Cost-Effectiveness of Influenza Vaccination in Children: Methodological Choices and Seasonal Variability},
  author={Anthony T. Newall and Juan Pablo Dehollain and Prudence Creighton and Philippe Beutels and James G. Wood},
BackgroundThe universal vaccination of children for influenza has recently been recommended in the UK and is being considered in other developed countries.ObjectivesThe aim of this study was to explore the potential costs and benefits of childhood influenza vaccination to gain a better understanding of the key drivers of cost-effectiveness.MethodsAs our case study we examined the cost-effectiveness of vaccination in Australian schoolchildren using an age-stratified Susceptible Exposed… 

Cost-effectiveness of vaccines for the prevention of seasonal influenza in different age groups: a systematic review

Scientific evidence shows that seasonal influenza vaccination programs in school-age children can be a cost-effective alternative from national health system perspective and can be cost-saving from societal perspective in European countries.

Cost-effectiveness of Strategies for Offering Influenza Vaccine in the Pediatric Emergency Department

Although few PEDs routinely offer influenza vaccination, doing so appears to be cost-effective, with the potential to significantly reduce the economic (and patient) burden of pediatric influenza.

Impact of vaccine herd-protection effects in cost-effectiveness analyses of childhood vaccinations. A quantitative comparative analysis

Inclusion of herd-protection effects in CEAs had a substantial impact in the estimated ICERs and made target-vaccination strategies more attractive options in almost half of the cases where ICers were above the societal-willingness to pay threshold without herd- protection.

On the influenza vaccination policy through mathematical modeling.

  • Bin-Shenq HoKun-Mao Chao
  • Medicine, Political Science
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2020

Vaccination of children with a live-attenuated, intranasal influenza vaccine – analysis and evaluation through a Health Technology Assessment

It can be concluded that there is high evidence for superior efficacy of LAIV (compared to placebo or TIV) among children aged 6 months to ≤7 years and for children aged >7 to 17 years, LAIV is superior to a vaccination with TIV (RRR 32%).

Protection of young children from influenza through universal vaccination

Although future research could lead to an increase in the immunogenicity and potential efficacy of influenza vaccines, the available vaccines assure sufficient protection in most subjects aged ≥ 6 months, thus reducing the total burden of influenza in young children and justifying the recommendation for the universal vaccination of the whole pediatric population.

WHO guide on the economic evaluation of influenza vaccination

The purpose of this guide is to outline the key theoretical concepts and best practice in methodologies and to provide guidance on the economic evaluation of influenza vaccination in LMICs.



Economic Evaluations of Childhood Influenza Vaccination

A literature search of economic evaluations of influenza vaccination in those aged ≤18 years revealed 20 relevant articles, which were reviewed and generally favourable for vaccination, but often applied a wider perspective than the reference case for economic evaluations used in many countries.

Evaluating the cost-effectiveness of vaccination programmes: a dynamic perspective.

It is shown that if cases of infection are the outcome of interest then the constant force of infection model will always underestimate the cost-effectiveness of the immunization programme except at the extremes when no one or everyone is immunized.

Cost-effectiveness analyses of vaccination programmes : a focused review of modelling approaches.

The results emphasize the need to improve modelling methods for CEAs of vaccination programmes; specifically, model choice, construction, assessment and validation.

Estimating the impact of school closure on influenza transmission from Sentinel data

It is shown that holidays lead to a 20–29% reduction in the rate at which influenza is transmitted to children, but that they have no detectable effect on the contact patterns of adults, as well as predicting the effect of school closure during a pandemic.

Vaccines for preventing influenza in the elderly.

The available evidence is of poor quality and provides no guidance regarding the safety, efficacy or effectiveness of influenza vaccines for people aged 65 years or older and an adequately powered publicly-funded randomised, placebo-controlled trial run over several seasons should be undertaken.

Economic Evaluation of Vaccination Programs: The Impact of Herd-Immunity

  • M. BrissonW. Edmunds
  • Medicine
    Medical decision making : an international journal of the Society for Medical Decision Making
  • 2003
The authors illustrate the importance of incorporating herd-immunity externalities when assessing the cost-effectiveness of vaccination programs by comparing 2 methods of estimating the benefits of routine mass vaccination: one that includes herd-IMmunity (dynamic approach) and one that does not (static approach).

Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial.

Imposing inactivated influenza vaccine on children and adolescents aged 36 months to 15 years significantly protected unimmunized residents of rural communities against influenza.