Understanding the Charge Issues in Mono and di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS

  title={Understanding the Charge Issues in Mono and di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS},
  author={Thirumurthy Velpandian and Jayabalan Nirmal and Beauty Arora and Alok Kumar Ravi and Ankita Kotnala},
  journal={Analytical Letters},
  pages={2367 - 2376}
Chromatographers often develop problems while optimizing a method for the quantification of quaternary ammonium compounds in ESI-MS/MS. Intransigency observed in quaternary ammonium compounds to undergo the classical molecular adduct formation [M+H]+ in ESI-MS/MS reduces confidence among chromatographers while working with unit mass resolution. In this study, we provide the evidence for an exceptional rule followed by mono- and di-quaternary ammonium compounds in ESI-MS/MS in the precursor ion… 
4 Citations
Development and validation of a LC-MS/MS method for homocysteine thiolactone in plasma and evaluation of its stability in plasma samples.
Hydrogen peroxide and sodium hypochlorite disinfectants are more effective against Staphylococcus aureus and Pseudomonas aeruginosa biofilms than quaternary ammonium compounds
In general, bactericidal efficacy against biofilms differed by active ingredient, and sodium hypochlorite and hydrogen peroxide disinfectants had significantly higher bactericidal efficacies than quaternary ammonium chloride disinfectants.


Formation of low charge state ions of synthetic polymers using quaternary ammonium compounds.
A comparison of structurally different quaternary ammonium compounds showed that the best performance is expected from large molecules with specific charge localization, which leaves the charge available for interactions in order to facilitate low charge state pseudomolecular ions.
Derivatization of peptides as quaternary ammonium salts for sensitive detection by ESI‐MS
Tandem mass spectrometric analysis of the peptide quaternary ammonium derivatives was shown to provide sequence confirmation and enhanced detection and offers a novel sensitive approach to analyze peptides and other compounds.
Analysis of quaternary ammonium compounds in estuarine sediments by LC-ToF-MS: very high positive mass defects of alkylamine ions as powerful diagnostic tools for identification and structural elucidation.
A sensitive and robust method of analysis for quaternary ammonium compounds (QACs) in marine sediments is presented, providing solutions to problems associated with analysis of QACs, such as dialkyldimethylammonium (DADMAC) and benzalkonium (BAC) compounds experienced previously.
Determination of diquat and paraquat in water by liquid chromatography-(electrospray ionization) mass spectrometry
Method for measurement of the quaternary amine compounds paraquat and diquat in human urine using high-performance liquid chromatography-tandem mass spectrometry.
On the stability of the organic dication of the bisquaternary ammonium salt decamethoxinum under liquid secondary ion mass spectrometry.
To reveal the structural and electronic parameters of decamethoxinum, which are responsible for the stabilization of its organic dication in the gas phase, a comprehensive SIMS study using metastable decay, collision-induced dissociation and kinetic energy release techniques complemented by ab initio quantum chemical calculations was performed.
Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: application to a pharmacokinetic study.
LC/MS/MS analysis of quaternary ammonium drugs and herbicides in whole blood.
Development and validation of a highly sensitive LC-MS/MS method for organic cation transporter (OCT) substrate tetraethylammonium (TEA) in rabbits.
[Determination of paraquat residue in plant-derived foodstuffs by high performance liquid chromatography-tandem mass spectrometry].
  • H. Bo
  • Medicine
    Se pu = Chinese journal of chromatography
  • 2011
A sensitive and selective method is presented for the determination of paraquat residue in fruits, vegetables, beans and grain by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), which can meet the requirements of international maximum residue limit.