Understanding the Charge Issues in Mono and di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS

@article{Velpandian2012UnderstandingTC,
  title={Understanding the Charge Issues in Mono and di-Quaternary Ammonium Compounds for Their Determination by LC/ESI-MS/MS},
  author={Thirumurthy Velpandian and Jayabalan Nirmal and Beauty Arora and Alok Kumar Ravi and Ankita Kotnala},
  journal={Analytical Letters},
  year={2012},
  volume={45},
  pages={2367 - 2376}
}
Chromatographers often develop problems while optimizing a method for the quantification of quaternary ammonium compounds in ESI-MS/MS. Intransigency observed in quaternary ammonium compounds to undergo the classical molecular adduct formation [M+H]+ in ESI-MS/MS reduces confidence among chromatographers while working with unit mass resolution. In this study, we provide the evidence for an exceptional rule followed by mono- and di-quaternary ammonium compounds in ESI-MS/MS in the precursor ion… 
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