Understanding smell—The olfactory stimulus problem

@article{Auffarth2013UnderstandingSO,
  title={Understanding smell—The olfactory stimulus problem},
  author={Benjamin Auffarth},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2013},
  volume={37},
  pages={1667-1679}
}
  • B. Auffarth
  • Published 1 September 2013
  • Biology, Psychology
  • Neuroscience & Biobehavioral Reviews

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References

SHOWING 1-10 OF 274 REFERENCES
Quantification of odor quality.
TLDR
This review scrutinizes how psychophysicists and others have measured quality and offers criteria for useful techniques, including nonsubjective techniques that have high sensitivity, can have counterparts in infrahuman research, are suitable to examine individual differences and yield non-negotiable answers with potential archival value.
Continuous Spatial Representations in the Olfactory Bulb may Reflect Perceptual Categories
TLDR
This work applies a statistical analysis on 2-deoxyglucose images taken over the entire bulb of glomerular layer of the rat to see how the recognition of odors in the nose is translated into a map of odor quality in the brain, and indicates that perceptual qualities could be represented as continuous spatial codes of the olfactory bulb glomerulus population.
A Large-Scale Analysis of Odor Coding in the Olfactory Epithelium
TLDR
These studies revealed extraordinary diversity, but also bias, in odorant recognition by the OSN, and thus OR, repertoire, indicating that most OSNs are narrowly tuned to detect a subset of odorants with related structures and often related odors, but that the repertoire also includes broadly tuned components.
A Molecular Vocabulary for Olfaction a
  • G. Shepherd
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 1987
Olfactory research is entering a new phase, in which molecular mechanisms are being revealed that go considerably beyond traditional concepts. New ways of characterizing these mechanisms are needed,
Relating Sensor Responses of Odorants to Their Organoleptic Properties by Means of a Biologically-Inspired Model of Receptor Neuron Convergence onto Olfactory Bulb
TLDR
The results suggest that convergence mapping combined with IR absorption spectra may be an appropriate method to capture perceptual characteristics of certain classes of odorants.
Humans and Mice Express Similar Olfactory Preferences
TLDR
It is shown that odor pleasantness rating in humans and investigation time in mice were both correlated with the physicochemical properties of the molecules, suggesting that olfactory preferences are indeed partly engraved in the physicochemistry structure of the odorant.
Distributed representation of chemical features and tunotopic organization of glomeruli in the mouse olfactory bulb
TLDR
Using a sensitive probe, the glomerular response to large numbers of odorants at single glomerulus resolution is analyzed and it is found that the representation of chemical features is spatially distributed in the olfactory bulb with no discernible chemotopy.
Chemotopic odorant coding in a mammalian olfactory system
TLDR
When glomerular activity patterns are viewed relative to the overall level ofglomerular activation, the patterns accurately predict the perception of odor quality, thereby supporting the notion that spatial patterns of activity are the key factors underlying that aspect of the olfactory code.
Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration
TLDR
It is suggested that changes in modular glomerular activity patterns could underlie altered odor perception across odorant concentrations, and they provide additional support for a combinatorial, spatially based code in the olfactory system.
In search of the structure of human olfactory space.
TLDR
It is argued that odorants densely sample a two-dimensional curved surface embedded in the multidimensional sensory space, thereby providing surrogates for olfactory sensory space and only 12% of experimental variance cannot be explained by curved surfaces of substantially small dimensionality.
...
...