Understanding sleep-wake mechanisms and drug discovery

  title={Understanding sleep-wake mechanisms and drug discovery},
  author={Ana Clementina Equihua-Ben{\'i}tez and Khalil Guzm{\'a}n-V{\'a}squez and Ren{\'e} Drucker-Col{\'i}n},
  journal={Expert Opinion on Drug Discovery},
  pages={643 - 657}
ABSTRACT Introduction: Although not discernible at first glance, sleep is a highly active and regulated brain state. Although we spend practically one third of our lifetimes in this stage, its importance is often taken for granted. Sleep loss can lead to disease, error and economic loss. Our understanding of how sleep is achieved has greatly advanced in recent years, and with that, the management of sleep disorders has improved. There is still room for improvement and recently many new… 

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