Understanding nucleotide excision repair and its roles in cancer and ageing

@article{Marteijn2014UnderstandingNE,
  title={Understanding nucleotide excision repair and its roles in cancer and ageing},
  author={Jurgen A Marteijn and Hannes Lans and W. Mary Vermeulen and Jan H. J. Hoeijmakers},
  journal={Nature Reviews Molecular Cell Biology},
  year={2014},
  volume={15},
  pages={465-481}
}
Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a multiwise 'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway prevents mutagenesis by probing the genome for helix-distorting lesions, whereas transcription-coupled NER (TC-NER) removes transcription-blocking lesions to permit unperturbed gene expression, thereby preventing cell death. Consequently, defects in GG-NER result in cancer predisposition, whereas defects in TC-NER cause a… CONTINUE READING
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